Santo Ângelo is a city located in northwestern Rio Grande do Sul state. City population is about 76,304 inhabitants. Neighboring city Giruá sits to the north and to the south of Santo Ângelo is the city of Entre-Ijuís both linked to the city by state road RS 344.
Tourism in the city is primarily associated with the city's Jesuit history and the Jesuit Reductions in nearby São Miguel das Missões. The Angelopolitana Cathedral in downtown Santo Ângelo is the seat of the Roman Catholic Diocese of Santo Ângelo.
The city is served by Sepé Tiaraju Airport.